Recent Research Offers Hope for Kidney Stone Prevention

A new technique to curb the growth of crystals in one type of kidney stone offers hope for preventing development of the hard deposits which can cause extreme pain, researchers reported Thursday.


Scientists at New York University's Department of Chemistry and its Molecular Design Institute, NYU School of Medicine, and the Medical College of Wisconsin sought to attack kidney stones at the molecular level by examining the crystals that form them.


The researchers used atomic force microscopy, which allows for the observation of objects as small as a nanometer, to observe the growth of the L-cystine crystals that make up one type of kidney stone.


Knowing how these crystals grew, the researchers could then select a chemical agent to inhibit this process.


"This may lead to a new approach to preventing cystine stones simply by stopping crystallization," said Michael Ward, one of the authors of the research and chair of NYU Department of Chemistry.


"Moreover, these findings are an example of the significant advances that can be achieved through collaborations between researchers in physical sciences and in medicine."

Kidney stones comprised of L-cystine affect an estimated 20,000 individuals in the United States.


This number is smaller than the number of Americans afflicted by calcium oxalate monohydrate (COM) stones, but L-cystine stones are larger, recur more frequently, and are more likely to cause chronic kidney disease.


Although they often cause no permanent damage, kidney stones can be extremely painful and sometimes are removed by surgery or sound waves.


Current medications for L-cystine stone prevention can cause adverse side effects such as nausea, fever, fatigue, skin allergies, and hypersensitivity.


The findings of the latest research appear in the October 15 issue of the journal Science.




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