Causes of Chronic Pelvic Pain Syndrome

1. Voiding dysfunction

1.1 Some factors lead to the excessive contraction of urinary sphincter, the obstruction of the bladder outlet, and the formation of residual urine, which results in the backflow of urine into the prostate.

1.2 There are many kinds of urodynamic changes in many prostatitis patients, which may be related to the underlying pathogenic factors

2. Pathogenic infection

Although routine bacterial examination failed to isolate pathogens, it may still be related to some special pathogens.

3. Mental factors

More than half of the patients with chronic pelvic pain syndrome(CPPS) have obvious changes in mental and psychological factors and personality characteristics.

4. Neuroendocrine

Patients with chronic pelvic pain syndrome are prone to fluctuations in heart rate and blood pressure, which may be related to autonomic nervous response.

5. Abnormal immune response

In recent years, studies have shown that immune factors play a very important role in the occurrence and development of type Ⅲ prostatitis, and immunosuppressive therapy has a certain effect.

6. Oxidative stress concept

The excessive production of oxygen free radicals and the reduction of the scavenging system of free radicals make nerve endings sensitized, which may also be one of the pathogenesis.

7. Pelvic diseases

The symptoms of some CPPS patients may be related to pelvic vein congestion and blood stasis, which may also be one of the reasons for the recurrent conditions.

8. Lower urinary tract epithelial dysfunction

Many studies have found that CPPS is similar to interstitial cystitis, which can be caused by a bacterial and viral infection of bladder or prostate, radiation, mast cell activation, neurogenic inflammation, mental tension, congenital or urinary tract damage to the mucous membrane.

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